Summary of the group: Pharmaceutical Sciences is a department within AstraZeneca Biopharmaceuticals R&D with a mission to transform molecules into investigational medicines, meeting the unmet needs of future patients.
Advanced Drug Delivery is a department within Pharmaceutical Sciences.
Our portfolio of projects spans traditional small molecules, peptides, oligonucleotides to RNA-based therapeutics across AstraZenecas therapy areas and our mission is to transform diverse modalities into investigational medicines.
Main Duties & Responsibilities: We are looking for a highly motivated chemist with a strong foundation in the delivery sciences to join the dynamic Advanced Drug Delivery group, engaging in the new modality projects in AstraZeneca pipeline.
Main responsibilities for this role include: Designing and synthesizing lipids for lipid nano-particle based delivery platform with minimum supervision; Analyzing and characterizing lipids and lipid nanoparticles with appropriate technologies; Generating, evaluating and reporting data clearly and reliably.
Acting as the delivery chemist/formulation subject matter expert on the delivery of nucleic acid therapeutics; Providing data interpretation and making recommendations to project teams and other stakeholders.
Collaborating with other Advanced Drug Delivery teams in Sweden & the UK.
Presenting data at internal AstraZeneca meetings and occasionally at external meetings.
Education & Experience Requirements: PhD degree in Polymer Chemistry, Organic Chemistry, Medicinal Chemistry, Pharmaceutical Sciences or related scientific disciplines with 0-5 years post-graduation experience in a pharmaceutical and/or biotechnology environment.
Required Skills: Demonstrated ability in designing and optimizing synthetic strategies and approaches of lipids and/or polymers Proficiency with analytical and physicochemical characterization of novel materials (e.g.
NMR, LC/MS, particle sizer, various separation technologies) Knowledge of novel delivery technologies including but not limited to microspheres, lipid based formulation, nanoparticles Track record of scientific excellence in terms of scientific publications, patents, and/or conference presentations Excellent oral and written communication skills Knowledge of new modalities (e.g.
oligonucleotides, RNA, DNA, peptides, proteins) Desired Skills: Experience with new modalities (e.g.
oligonucleotides, RNA, DNA, peptides, proteins) Experience with outsourcing is a plus Experience with formulation and pharmaceutical sciences Experience with bio-conjugation