Goodall Brazier are partnered with an exciting CDMO, specializing in the manufacturing of peptides, oligonucleotides and related compounds.
This position will be based in Los Angeles, California and looking to develop, implement and maintain all aspects of the Oligonucleotide Program.
Primary responsibilities: Synthesis of oligonucleotides, C&D, purification, desalting and lyophilization of oligonucleotides to support projects in multiple disease area Design and execute various bioconjugation strategies and techniques to prepare novel oligonucleotide conjugates Optimization and scale up of downstream processing methods Ability to operate and maintain lab instruments such as ÄKTA synthesizers, purifiers, HPLC and LC-MS in good operational conditions Present results clearly in both written and oral format Develop batch records, SOPs and training materials Diligently partner with QA and QC peers Strict adherence to current good manufacturing practices (cGMP), standard operating procedures (SOP), and manufacturing documentation As a technical expert, provide oligonucleotide process perspectives to other teams in the organization engaged in the development of our end-to-end manufacturing process Write research reports and present results internally and externally Write and review manufacturing procedures and documentation used in the Oligonucleotide Laboratories Perform other duties as assigned Position requirements: Minimum BS in chemistry or similar Minimum experience 2 years in a GMP manufacturing facility Strong knowledge of oligonucleotide techniques Technical writing Excellent communication skills are a must CDMO experience is a plus