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Senior Associate Scientist – Mass Spectrometry (Lead Discovery)

Amgen

This is a Contract position in Los Angeles, CA posted August 2, 2022.

HOW MIGHT YOU DEFY IMAGINATION?

Youve earned your degree.

How will you use that achievement to reach your goals?

Do more with the knowledge youve worked hard to acquire and the passion you already have.

At Amgen, our shared missionto serve patientsdrives all that we do.

It is key to our becoming one of the worlds leading biotechnology companies, reaching over 10 million patients worldwide.

Become the professional you are meant to be in this meaningful role.

Senior Associate Scientist Mass Spectrometry (Lead Discovery) Live What you will do Lets do this.

Lets change the world.

Amgen is a biopharmaceutical leader founded on discovering, developing, manufacturing, and delivering innovative human therapeutics.

Amgen’s Lead Discovery and Characterization laboratory within Therapeutic Discovery is seeking a highly motivated small molecule Mass Spectrometry expert at Amgen headquarters in Thousand Oaks, CA.

The successful candidate will be responsible primarily for the development of label-free technologies to monitor and quantify protein-ligand interactions, including screening and characterizing small molecule ligands by Mass Spectrometry.

Additional responsibilities may include the development and execution of mass spectrometric-based characterization of protein-small molecule adducts (e.g.

native MS or affinity selection MS) as part of our efforts toward the discovery of new drugs.

The successful candidate will work closely with biology and chemistry teams to develop new assays and strategies, analyze results, and present and discuss high quality data in a timely manner and should also contribute to skills development and mentoring for colleagues in a highly multi-disciplinary environment.

In this vital role you will [top-line statement connecting primary position responsibility to employer brand].

Win What we expect of you We are all different, yet we all use our unique contributions to serve patients.

The dynamic professional we seek is a scientist with these qualifications.

Basic Qualifications: Masters degree and 3 years of scientific experience Or Bachelors degree and 5 years of scientific experience Preferred Qualifications: Doctoral degree with 2 years of mass spectrometry experience.

Deep knowledge of small molecule MS techniques, especially as applied to monitoring of enzyme reactions for quantitative analysis of protein-ligand interactions.

Experience with the operation, troubleshooting, and maintenance of Q-TOF, QQQ, and/or MALDI mass spectrometers, including the use of LC, SPE, or SEC separation techniques.

Familiarity with Agilent, SCIEX, and Bruker instrumentation and software e.g.

Agilent MassHunter and SCIEX MultiQuant software.

Experience in the development of SPE-MS or MALDI-TOF methods for MS-detected enzyme assays, or to characterize protein-small molecule adducts.

Experience with high-throughput data analysis packages (e.g.

Genedata Screener).

Familiarity with the principles of high-throughput screening (HTS) and experience with microplate readers and automated liquid handling systems.

An understanding of mechanistic enzymology and biophysical assays (SPR, ITC, NMR) for characterization of protein-ligand binding.

Demonstrated ability to work both independently and as a member of a multidisciplinary team.

Excellent written and oral communication skills for the timely documentation, presentation, and discussion of science-based results and strategy in a dynamic, multi-disciplinary, team-based environment.

Thrive Some of the vast rewards of working here As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being.

Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act Generous Total Rewards Plancomprising health, finance and wealth, work/life balance, and career benefitswith compensation and benefits rated above 4 stars (out of 5) on Glassdoor Apply now for a career that defies imagination Objects in your future are closer than they appear.

Join us.

careers.amgen.com Join Us If you’re seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you’ll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics.

Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win.

Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

Please contact us to request accommodation.

Amgen requires all staff in the United States, Puerto Rico and Canada to be vaccinated from COVID 19 as a condition of employment.

In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance.

Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.