Senior Associate Scientist – E3 Ligase Biology

HOW MIGHT YOU DEFY IMAGINATION?

Youve earned your degree.

How will you use that achievement to reach your goals?

Do more with the knowledge youve worked hard to acquire and the passion you already have.

At Amgen, our shared missionto serve patientsdrives all that we do.

It is key to our becoming one of the worlds leading biotechnology companies, reaching over 10 million patients worldwide.

Become the professional you are meant to be in this meaningful role.

Senior Associate Scientist E3 Ligase Biology Live What you will do We are seeking a highly creative and motivated scientist to join our rapidly growing team as a Senior Associate Scientist.

The scientist will be part of Amgens Induced Proximity Platform (IPP) team focused on tackling the undruggable genome through Targeted Protein Degradation.

The scientist will assist in broadening our understanding of E3 ubiquitin ligases towards the development of next generation therapeutics like PROTACs and molecular GLUEs.

These approaches will be applied to tackling challenging targets in diverse therapeutic areas, such as Cardiovascular biology and Immuno-Oncology.

Primary Responsibilities: Design, perform, and analyze experiments to understand E3 ligase activity in various systems and tissues Develop innovative platforms and modalities using engineered cell lines, chemical profiling, and activity-based probes Validate targets to inform decision making for PROTAC and Molecular GLUE design Gain experience in setting project goals and timelines, interacting with team members across different departments and research sites, and communicating and presenting data to diverse audiences Contribute to the scientific community through conference presentations and impactful publications Win What we expect of you We are all different, yet we all use our unique contributions to serve patients.

The qualified professional we seek is a Senior Associate Scientist with these qualifications.

Basic Qualifications Doctorate degree or Masters degree and 4 years of relevant scientific experience or Bachelors degree and 6 years of relevant scientific experience Preferred Qualifications Broad knowledge of cell and molecular biology with demonstrated independent research eminence through first author publications in top journals Prior experience with current biochemical, biophysical, molecular and cellular biology techniques, including cellular and enzymatic assay development, generation of stable cell lines using lentivirus, sample preparation for mass spectrometry, and mechanistic studies of enzymes Experience in the regulation of protein modification and degradation Excellent organizational, interpersonal, and communication skills Flexibility to work in teams to achieve project goals and meet timelines Strong experience with interpreting and analyzing complex data sets Thrive Some of the vast rewards of working here As we work to develop treatments that take care of others, so we work to care for our teammates professional and personal growth and well-being.

Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act Generous Total Rewards Plancomprising health, finance and wealth, work/life balance, and career benefitswith compensation and benefits rated above 4 stars (out of 5) on Glassdoor APPLY NOW Objects in your future are closer than they appear.

Join us.

careers.amgen.com .

Equal Opportunity Statement Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

Please contact us to request an accommodation.

Amgen requires all staff in the United States and Puerto Rico to be vaccinated from COVID 19 as a condition of employment.

In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance.

Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.

Join Us If you’re seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you’ll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics.

Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win.

Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

Please contact us to request accommodation.

Amgen requires all staff in the United States, Puerto Rico and Canada to be vaccinated from COVID 19 as a condition of employment.

In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance.

Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.

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