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Process Development Scientist – Technology

Amgen

This is a Contract position in Los Angeles, CA posted August 2, 2022.

HOW MIGHT YOU DEFY IMAGINATION?

Youve earned your degree.

How will you use that achievement to reach your goals?

Do more with the knowledge youve worked hard to acquire and the passion you already have.

At Amgen, our shared missionto serve patientsdrives all that we do.

It is key to our becoming one of the worlds leading biotechnology companies, reaching over 10 million patients worldwide.

Become the professional you are meant to be in this meaningful role.

Process Development Scientist Live What you will do Lets do this.

Lets change the world.

Responsibilities: Characterizing candidate molecules to support protein primary structure as well as characterizing drug candidate chemical and post-translational modifications (quality attributes) and their susceptibility to modification during the process and product development activities.

This includes the use of mass spectrometry coupled with a variety of separation techniques, including liquid chromatography (reversed-phase, size-exclusion, cation-exchange) and capillary zone electrophoresis to identify, characterize, and quantitate quality attributes.

LC-MS analysis of intact therapeutic proteins and LC-MS/MS peptide mapping.

Focus on developing novel sample preparation and MS-based technologies to reduce time and material requirements during all phases of candidate selection.

This role will also emphasize mass spectrometric method development and application for product characterization, including primary structure/glycan structure elucidation.

Generation of technical documents and technical presentations is required.

Working as part of a cross-functional team to define strategies for protein mass spectrometry testing, performing complex data analyses, and developing high throughput methods to monitor attributes.

Requires ability to work collaboratively with other scientists on multidisciplinary teams.

Additional responsibilities include keeping current with the field of expertise, including literature and technology development.

Responsible for providing scientific results that support the generation of publications, patents, and regulatory submissions, participating in recruiting and candidate evaluation, exploring and evaluating emerging technologies relevant to MS-based characterization of therapeutic proteins, and supervising and analyzing driven scientific knowledge from external sources.

Win What we expect of you We are all different, yet we all use our unique contributions to serve patients.

Basic Qualifications: Doctorate degree OR Masters degree and 4 years of experience OR Bachelors degree and 6 years of experience Preferred Qualifications: Ph.D.

in biological sciences, analytical chemistry, biochemistry, pharmaceutical sciences, physical sciences, chemical engineering Expertise with mass spectrometry of proteins, peptides, and glycans.

Expertise with Thermo mass spectrometers, Agilent and Waters HPLC systems, and corresponding data acquisition software such as Chromeleon and Empower.

Expertise with one of the mass spectrometry data processing software packages (BioPharma Finder, Byonic, Byos, Expressionist, Pinpoint, Skyline) Expertise with statistical software, including Excel, is recommended Experience within the biotech industry, experience including data analyses, statistical analysis, setting acceptance criteria in support of process development, process/method transfers, and comparability studies is a plus.

Good problem-solving skills requiring the application of scientific theory Ability to demonstrate skills in independently determining and developing scientific analysis and solutions, as well as demonstrate strong laboratory work skills to include the design and performance of scientific experiments and interpretation of results.

Excellent written and oral communication skills for the timely documentation, presentation, and discussion of scientific results in a fast-paced, multi-disciplinary environment.

Thrive Some of the vast rewards of working here As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being.

Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act Generous Total Rewards Plancomprising health, finance and wealth, work/life balance, and career benefitswith compensation and benefits rated above 4 stars (out of 5) on Glassdoor Apply now for a career that defies imagination Objects in your future are closer than they appear.

Join us.

careers.amgen.com Join Us If you’re seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you’ll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics.

Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win.

Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

Please contact us to request accommodation.

Amgen requires all staff in the United States, Puerto Rico and Canada to be vaccinated from COVID 19 as a condition of employment.

In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance.

Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.