Job Description Janssen Research & Development, L.L.C., a division of Johnson & Johnsons Family of Companies, is recruiting for a Principal Scientist, Translational PK/PD Modeling, located in San Diego, CA (La Jolla, CA area) or Spring House, PA.
At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease.
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Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.
The candidate is expected to have a leadership role in utilizing Pharmacokinetic/ Pharmacodynamic (PK/PD) modeling to drive project team decisions from early discovery through early clinical studies, as well as play a key role guiding modeling and simulation strategies within the organization.
The candidate will be a key member of discovery project teams and interact closely with biology, chemistry, and other drug metabolism and pharmacokinetic (DMPK) project members to help design the most appropriate preclinical and early clinical studies and the associated quantitative model-based analyses to inform candidate selection and dosing recommendations.
Modeling approaches used may include physiologically-based pharmacokinetic modeling, mechanistic PK/PD modeling, and/or systems pharmacology modeling to help (a) predict preclinical and clinical PK profiles (b) quantify exposure/ response relationships for target engagement biomarkers, efficacy, and potential adverse effects, and (c) guide in vivo and in vitro experimental designs that will be most informative for modeling.
Qualifications PhD in Pharmacology, Engineering, Mathematics, Physics, or related fields is required At least 6 years of relevant industry experience is required A strong understanding of DMPK principles and experience in supporting drug discovery and/or development as a PK/PD modeler are required.
Proven skills in modeling and simulation, supported by a strong publication track record is highly desired.
The candidate must possess excellent interpersonal, organizational, oral/written communication and teamwork skills.
This position can be based out of San Diego, CA (La Jolla area) or Spring House, PA, and may require approximately 10% travel.
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
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