The Merchant lab applies cutting edge immune profiling modalities to study the immune system in patients with hematologic malignancies. We are looking for an immunologist with an interest in translational medicine to lead laboratory studies related to clinical trials that are currently in progress and to help design appropriate laboratory correlates for clinical trials that are being planned. In particular, we are interested in understanding the function of NK and T cell biology in the context of allogeneic bone marrow transplant, adoptive cell transfer, CART cells, bi-specific immune cell engagers (BiTE), and oncolytic virus therapy. Our lab runs the imaging mass cytometry/CyTOF core facility at Cedars-Sinai. Imaging mass cytometry allows for highly multiplexed (35+ markers) imaging of immune and tumor cells, with spatial information and subcellular resolution. Imaging mass cytometry can be applied to all tissue types including cell lines, organoid, frozen section and FFPE fixed archival tissue. The lab also has projects that test immune therapies in xenograft models of human tumor and transgenic mouse models that would offer opportunities to perform mechanistic studies related to tumor immunology. Collaborations with other investigators at Cedars-Sinai allows access to single cell RNAseq, mass spec proteomics, and metabolic studies of immune cells.
In addition the Postdoctoral Scientist will be responsible for the following:
- Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator.
- Will assist in preparation of grant proposals, but is not responsible for generating grant funds. Will be encouraged to apply for fellowships as part of career development
- Will participate in publications and presentations as author or co-author.
- Will develop, adapt, and implement new research techniques and protocols.
- May develop, adapt, and implement new research techniques and protocols.
- Analyzes, interprets, summarizes and compiles data.
- Performs routine and complex laboratory procedures throughout training period.
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Requirements:
- Ph.D. or equivalent doctorate within previous three years
- Doctorate (MD, PhD, VMD, or DDS) in area directly related to field of research specialization. Graduate work with a focus on immunology, tumor immunology and/or NK cell biology.
Experience:- Works independently on research projects designed by a mentor (typically the PI) within area of specialization.
- Acquires thorough technical and theoretical knowledge of research project and objectives during one to five (1-5) year post-doctoral appointment.
- Prior work with adoptive cell transfer, CART work, iPS derived immune cells
- Experience with high dimension flow cytometry or CyTOF
- Experience with single cell RNAseq
- Tags: Los Angeles, CA